(Juvenile Pernicious Anemia; Congenital Pernicious Anemia)
|Red Blood Cells|
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- Atrophic gastritis (inflammation of the stomach)
- Removal of all or part of the stomach
Immune system reaction to:
- Intrinsic factor—a protein necessary for vitamin B12 absorption
- Cells that produce both intrinsic factor and hydrochloric acid in the stomach
- Autoimmune disorders and other conditions, such as:
- Ancestry: northern European or Scandinavian
- Age: over 50 years old
- Sensation of pins and needles in feet or hands
- Alternating constipation and diarrhea
- Stinging sensation on the tongue, or a smooth red tongue
- Substantial weight loss
- Inability to distinguish the colors yellow and blue
- Loss of hunger
- Altered sense of taste
- Impaired sense of balance, especially in the dark
- Ringing in the ears
- Cracked lips
- Inability to sense vibrations in feet or legs
- Dizziness when changing to standing position
- Rapid heart rate
- Complete blood count (CBC)—a count of the number of red and white blood cells in a blood sample
- Vitamin B12 level—a test that measures the amount of vitamin B12 in the blood
- Methylmalonic acid (MMA) level—a measurement of the amount of methylmalonic acid in the blood; this test determines whether a vitamin B12 deficiency exists.
- Homocysteine level—a test that measures the amount of homocysteine in the blood (homocysteine is a building block of protein)
- Schilling test—a test in which a harmless amount of radiation is used to assess the amount of stored vitamin B12 (rarely used)
- Red blood cell folate level—a measurement of the amount of a B vitamin called folate
- Intrinsic factor assay—a measurement of the amount of a protein called intrinsic factor normally produced by the stomach
- Bone marrow staining—a test that shows whether an iron deficiency exists
Vitamin B12 Injections
Oral Vitamin B12 Supplement
Intranasal Vitamin B12
Oral Iron Therapy
- Avoid over-consuming alcohol.
- Have your doctor check you for signs of iron deficiency.
- Undergo testing if your doctor suspects you are infected with the bacterium Helicobacter pylori .
Family Doctor http://familydoctor.org/
National Institutes of Health Office of Dietary Supplements http://ods.od.nih.gov/index.aspx/
Health Canada http://www.hc-sc.gc.ca/index-eng.php/
Public Health Agency of Canada http://www.phac-aspc.gc.ca/chn-rcs/index-eng.php/
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- Reviewer: Kari Kassir, MD
- Review Date: 09/2012 -
- Update Date: 03/28/2013 -