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Blake Medical Center

Treatments for Myelodysplastic Syndrome (MDS)

While standard protocols have been established for the treatment of virtually all cancers, doctors will often modify them for their individual patients. These modifications are based on many factors including the patient’s age, general health, desired results, and the specific characteristics of this cancer.

There is only one generally recognized curative treatment for MDS—allogenic stem cell transplant (SCT), or bone marrow transplant (BMT). SCT may be done in otherwise healthy patients.

Chemotherapy is used to treat advanced MDS. This treatment can have serious side effects and may not be an option for all patients, especially those who are elderly.

Certain medications have also helped treat the disease. A drug called a hypomethylating agent has shown positive results in treating MDS. These drugs work by slowing down cell growth. Some patients have shown improved blood counts, reduced risk of leukemia, and a longer life with these drugs. Immunomodulating drugs are also used to treat MDS. These drugs alter the immune system. Immunosuppressant drugs are used to treat certain types of MDS.

All other interventions are supportive and depend on which family of blood cells is involved. The mainstays of treatment have been blood component transfusions to replace the deficient cell types and antibiotics to treat the infections. Radiation therapy is not used for the treatment of MDS.

Clinical Trials

Treatment protocols have been established and continue to be modified through clinical trials. The research studies are essential to determine whether or not new treatments are both safe and effective. Since highly effective treatments for many cancers remain unknown, numerous clinical trials are always underway around the world. You may wish to ask your doctor if you should consider participating in a clinical trial. You can find out about clinical trials at the National Institutes of Health.

Revision Information

  • Castro-Malaspina H, O’Reilly RJ. Aplastic anemia and the myelodysplastic syndromes. In Harrison's Principles of Internal Medicine. 14th ed. New York, NY: McGraw-Hill; 1998.

  • Myelodysplastic syndrome in children. Boston Children's Hospital website. Available at:

  • Myelodysplastic syndromes. American Cancer Society website. Available at: Accessed December 20, 2014.